Lung cancer remains one of the leading causes of cancer-related deaths worldwide, including in Kerala. With advancements in medical oncology, targeted therapy has revolutionized the way lung cancer is treated. Unlike conventional chemotherapy, which affects both healthy and cancerous cells, targeted therapy is designed to specifically attack cancer cells based on their genetic and molecular characteristics.
At Dr. Bibin Francis Oncology, patients in Thrissur have access to cutting-edge targeted therapies tailored to their tumor profile, ensuring more effective treatment with fewer side effects.
Understanding Targeted Therapy in Lung Cancer
Targeted therapy is particularly effective for non-small cell lung cancer (NSCLC), which accounts for about 85% of lung cancers. It focuses on specific genetic mutations or pathways that drive cancer growth. Common actionable mutations in lung cancer include:
EGFR (Epidermal Growth Factor Receptor) mutations
ALK (Anaplastic Lymphoma Kinase) rearrangements
ROS1 gene fusions
BRAF mutations
PD-L1 expression (for immunotherapy-based targeted therapy)
Dr. Bibin Francis uses advanced diagnostic tools, including molecular profiling and genetic testing, to identify patients eligible for targeted therapy in Thrissur.
How Targeted Therapy Works
Targeted therapies interfere with the cancer cell’s growth mechanisms by:
Blocking abnormal proteins that drive cell growth
Interrupting signaling pathways that promote tumor proliferation
Triggering cancer cell death while sparing normal cells
Enhancing immune system recognition of cancer cells (in immunotherapy-based targeted therapy)
This precision approach allows patients to experience effective cancer control with fewer systemic side effects compared to traditional chemotherapy.
Types of Targeted Therapy
| Targeted Therapy Type | Examples | Mechanism of Action | Ideal Patient Profile | Common Side Effects |
|---|---|---|---|---|
| EGFR Inhibitors | Erlotinib, Gefitinib, Osimertinib | Blocks EGFR protein to prevent cancer growth | NSCLC patients with EGFR mutations | Rash, diarrhea, fatigue, mild liver enzyme changes |
| ALK Inhibitors | Crizotinib, Alectinib, Brigatinib | Inhibits ALK gene rearrangements | NSCLC patients with ALK-positive tumors | Nausea, vision changes, fatigue, swelling |
| ROS1 Inhibitors | Crizotinib | Blocks ROS1 fusion proteins | NSCLC patients with ROS1-positive tumors | Fatigue, nausea, mild liver function changes |
| BRAF Inhibitors | Dabrafenib, Trametinib | Blocks BRAF V600E mutation pathway | NSCLC patients with BRAF mutations | Fever, skin rashes, fatigue, joint pain |
| PD-1/PD-L1 Inhibitors | Pembrolizumab, Nivolumab | Enhances immune system attack on cancer cells | NSCLC patients with high PD-L1 expression | Fatigue, immune-related side effects (thyroid, liver, skin) |
Benefits of Targeted Therapy
Precision Treatment: Directly attacks cancer cells, sparing healthy tissues
Improved Survival: Increases progression-free survival for patients with actionable mutations
Fewer Side Effects: Better tolerability than chemotherapy
Convenient Administration: Many therapies are oral medications or periodic infusions
Effective in Advanced Cancer: Can manage metastatic disease and improve quality of life
Managing Side Effects
Although targeted therapy is generally safer than chemotherapy, patients may experience:
Skin rashes or acne-like lesions
Diarrhea or nausea
Mild liver function changes
Fluid retention or swelling
Dr. Bibin Francis in Thrissur provides regular monitoring, supportive care, and guidance to manage these side effects, ensuring patients maintain optimal quality of life.
Who Should Consider Targeted Therapy?
Targeted therapy is suitable for lung cancer patients whose tumors carry specific genetic mutations. Molecular testing is essential to determine eligibility.
Patients with advanced or metastatic NSCLC
Patients with recurring lung cancer after standard treatments
Patients seeking personalized therapy based on tumor genetics
Dr. Bibin Francis ensures every patient receives a tailored treatment plan, combining targeted therapy with other interventions like surgery, chemotherapy, or immunotherapy as needed.
Lifestyle and Supportive Measures
While targeted therapy is powerful, lifestyle modifications can enhance effectiveness and well-being:
Balanced Diet: Focus on vegetables, fruits, lean proteins, and whole grains
Regular Exercise: Helps reduce fatigue, strengthen immunity, and maintain weight
Avoid Smoking & Alcohol: Both can interfere with treatment efficacy
Routine Monitoring: Regular imaging and blood tests to track response
Mental Health Support: Counseling and support groups can reduce stress and anxiety
Why Choose Dr. Bibin Francis for Lung Cancer Care in Thrissur?
Expertise in Lung Cancer: Years of experience in advanced lung cancer management
Precision Oncology: Personalized treatment based on genetic testing and tumor profiling
Patient-Centered Care: Emphasis on comfort, quality of life, and holistic management
Access to Latest Therapies: EGFR, ALK, ROS1, BRAF inhibitors, and immunotherapy
Comprehensive Support: Side effect management, nutrition, counseling, and follow-up care
Is targeted therapy painful?
Most targeted therapies are oral medications or infusions and generally painless, though mild side effects may occur.
How do I know if targeted therapy is right for me?
Eligibility is determined through genetic and molecular testing of the tumor.
How long is the treatment course?
Duration varies depending on tumor response and tolerability, often continued as long as it is effective.
Can targeted therapy be combined with other treatments?
Yes, it can be combined with chemotherapy, immunotherapy, or surgery for better outcomes.
Will targeted therapy cure lung cancer?
While not always curative in advanced cases, targeted therapy can control disease, shrink tumors, and improve survival and quality of life.
Conclusion
Targeted therapy represents a breakthrough in personalized lung cancer treatment, offering precision, efficacy, and improved quality of life. Patients in Thrissur can benefit from Dr. Bibin Francis’ expertise, advanced diagnostics, and compassionate care, ensuring a treatment plan tailored to their unique needs.
For patients seeking advanced lung cancer treatment with fewer side effects and personalized care, consulting Dr. Bibin Francis is the first step toward a better treatment outcome.